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Mohammed F. AL-Marjani*, Zahraa A. Khadam
Department of Biology, College of Science Al- Mustansiriyah University,
Baghdad – Iraq
*Address for Corresponding author
Mohammed F. Al- Marjani ,
Prof. of Microbiology in College of Science , Al- Mustansiriyah University, Baghdad-Iraq.
Abstract
Antibiotic resistance is a problem of deep scientific concern both in hospital and community settings. Production of extended-spectrum b-lactamases (ESβLs) is a significant resistance-mechanism that impedes the antimicrobial treatment of infections caused by Enterobacteriaceae and is a serious threat to the currently available antibiotic armory. Metallo-β-lactamases have emerged worldwide as a major source of acquired broad-spectrum β-lactam resistance. Multidrug resistant A. baumannii, is now recognized to be of great clinical significance. Many reports relay to the spread of A. baumannii in the hospital settings which leads to enhanced nosocomial outbreaks associated with high death rates. Our review will focus on the evolution and the emergence of multidrug resistance A. baumannii in Iraq as well as the types of the beta lactamase genes in relation with the predominant ESBL-genes circulating Iraqi’s hospitals. Therefore, we have analysed the results from Iraq during the last 15 years. This review showed the predominance of blaCTXM gene group in A. baumannii in Iraq.We conclude that the spread of CTX-M group in Iraq reflects the global emergence of CTX-M β-lactamases in A. baumannii isolates.
Keywords: Acinetobacter; Multi-drug resistance; β-lactamases
