Research Articles

2025  |  Vol: 10(4)  |  Issue: 4(July-August) | https://doi.org/10.31024/apj.2025.10.4.1

Preformulation and compatibility study of Propranolol hydrochloride and herbal excipients

Ajay Kumar Shukla*, Vimal Kumar Yadav, Vishnu Prasad Yadav, Atul Shukla, Om Prakash Yadav

Institute of Pharmacy, Dr Rammanohar Lohia Avadh University Ayodhya U.P. India

*Address for Corresponding author

Dr. Ajay Kumar Shukla

Institute of Pharmacy, Dr Rammanohar Lohia Avadh University Ayodhya U.P. India

---

Abstract

The objective of the present research work was preformulation study and physicochemical compatibility between synthetic drugs and their herbal excipients for advanced drug delivery. Propranolol HCl drug were selected as water soluble model drug, and where tamrind seed gum (TSG) and fenugreek seed gum (FSG) used as excipients. The preformulation study and physicochemical compatibility between synthetic drugs and herbal excipients studies were done by UV (Ultra-Violet Spectroscopy), Fourier transform infrared spectroscopy (FTIR), Thin layer chromatography (TLC) High Performance Liquid Chromatography (HPLC) and Differential Scanning Calorimetry (DSC). FTIR spectrophotometric graphs showed that there was no significant alteration occurred in position of functional groups in pure drugs and their herbal excipients with respect to their physical mixtures, represented that the characteristic peaks of drug appeared which showing that drug and their excipients was present as a crystalline form as well. The R_f values of the physical mixtures obtained from TLC study on the 0th and 30th day were approximately similar to the R_f values of the pure drug and herbal excipients. All of the experimental results and retention factor clearly validated that the synthetic-herbal drug combinations with pharmaceutical excipients are compatible with each other and can be utilized for successful development of different dosage formulations.

Keywords: Compatibility study, TLC, propranolol, Tamarind, Fenugreek