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Evaluation of cytotoxicity potential of Garcinia cambogia (Gaertn.) Desr. male flower extract using Allium cepa model Advance Pharmaceutical Journal

Research Articles

2023  |  Vol: 8(5)  |  Issue: 5(September-October) | https://doi.org/10.31024/apj.2023.8.5.2
Evaluation of cytotoxicity potential of Garcinia cambogia (Gaertn.) Desr. male flower extract using Allium cepa model

Shilpa K.J.*, Krithi Puthukulathil Gopi, Aswathi Muzhapravan, Kavya Prabhakaran Kinattumkara

Department of Botany, Jnana Kaveri P.G. Centre Chikka Aluvara, Mangalore University, Kodagu, India

*Address for Corresponding Author

Shilpa K. J.

Department of Botany, Jnana Kaveri P.G. Centre Chikka Aluvara, Mangalore University, Kodagu, India

 

Abstract

The cytotoxic and genotoxic effects of various solvent extracts of Garcinia cambogia male flower was carried out using Allium cepa model. The solvents such as distilled water, ammonia, ethyl acetate and hexane were used for extraction. The percent mitotic index of all extracts decreased with increase in extract concentrations. A dose dependent decrease in root length with an increase in the extract concentration was also observed. The results revealed aberrations such as chromosome bridge, nuclear lesions, vagrant chromosomes, c- metaphase, abnormal separation and disturbed metaphase. Hence it can be concluded from the results that the plant extracts are cytotoxic and genotoxic in nature.

Keywords: Aberration, Allium cepa, cytotoxicity, Garcinia cambogia, mitotic index, vagrant

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